Analysis of SecA2-dependent Substrates in Mycobacterium marinum Identifies Protein Kinase G (PknG) as a Major Virulence Effector
نویسندگان
چکیده
1Department of Medical Microbiology and Infection Control, VU University Medical Center, van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands; 2Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, de Boelelaan 1085, 1081 HV Amsterdam, the Netherlands; 3Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland 4Department of Medical Oncology, OncoProteomics Laboratory, VU University Medical Center, de Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; 5Institut Pasteur Pathogénomique Mycobactérienne Intégrée, 25 Rue du Docteur Roux, 75724 Paris, France
منابع مشابه
Analysis of SecA2-dependent substrates in Mycobacterium marinum identifies protein kinase G (PknG) as a virulence effector.
The pathogenicity of mycobacteria is closely associated with their ability to export virulence factors. For this purpose, mycobacteria possess different protein secretion systems, including the accessory Sec translocation pathway, SecA2. Although this pathway is associated with intracellular survival and virulence, the SecA2-dependent effector proteins remain largely undefined. In this work, we...
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